Raymond "Red" Reddington, one of the FBI's most wanted fugitives, surrenders in person at FBI Headquarters in Washington, D.C. He claims that he and the FBI have the same interests: bringing down dangerous criminals and terrorists. In the last two decades, he's made a list of criminals and terrorists that matter the most but the FBI cannot find because it does not know they exist. Reddington calls this "The Blacklist". Reddington will co-operate, but insists that he will speak only to Elizabeth Keen, a rookie FBI profiler.
In the two years following the death of Elizabeth Keen, Raymond Reddington and the members of the FBI Task Force have disbanded with Reddington's whereabouts unknown. When one of their own is injured in the line of duty, however, the Task Force is drawn back together to bring down a conspiracy that could shatter global security.
A kidnapping poses a test for the capabilities of the Task Force as they contend with a mysterious pirating organization.
A new case involving stolen artifacts reunites Red with a former blacklister. Aram faces a difficult decision.
The Task Force races to locate a blacklister who uses any means necessary to return what has been unjustly stolen. Ressler asks Park for a favor. Cooper tries to piece together an event for which he has no memory.
Dembe's position as an FBI agent causes complications for Red as the Task Force handles a case involving military technology. Cooper and Park each find their personal lives increasingly complicated.
The Task Force investigates a therapist who may be the key to the resurgence of an organized crime family. Red conducts an investigation of his own.
In a series of flashbacks, Ressler recalls his actions in the aftermath of Elizabeth Keen's death.
The death of a professional tennis player leads the Task Force to a doctor who may be fixing the odds for a major sports betting syndicate. Red digs deeper into Dembe's betrayal. Ressler struggles with sobriety.
A spate of coordinated attacks on Red's lieutenants puts Dembe in imminent danger, prompting him to relive the events that led him to join the FBI two years earlier.